Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma (2024)

Kim, M. S., Lee, H. W., Jun, S. Y., & Lee, E. H. (2015). Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma. International Journal of Clinical and Experimental Pathology, 8(8), 8842-8856.

Kim, Mee Seon ; Lee, Hyoun Wook ; Jun, Si Youl et al. / Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma. In: International Journal of Clinical and Experimental Pathology. 2015 ; Vol. 8, No. 8. pp. 8842-8856.

@article{9ca1db77a8c74f22b544dc35b5aecb90,

title = "Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma",

abstract = "Alpha B crystallin was characterized as a negative prognostic factor in breast cancer. BCL2 has an antiapoptotic role and sustains cell survival in vitro, ironically BCL2 expression has been associated with a good prognosis of breast cancer patients. To investigate the significance of alpha B crystallin and BCL2 expression in breast cancer and the relationship between these proteins, we performed immunohistochemical staining for both proteins in human breast cancer tissues. In the present study, overexpression of alpha B crystallin was observed more frequently in triple negative cancer (9/20, 45%) than in luminal type cancer (8/53, 15.1%, P=0.02161). BCL2 tended to be more highly expressed in luminal type cancer than in HER2 and triple negative cancer types (luminal: 36/53, 68%, HER2: 2/9, 22%, triple negative: 7/20 35%, P=0.008652). In multivariate analysis using ANCOVA, alpha B crystallin was related to short overall survival (P=0.017173). These findings suggest that alpha B crystallin is an independent prognostic factor of infiltrating ductal carcinoma. BCL2 was not associated with survival in multivariate analysis using ANCOVA. Thus, in our study BCL2 was not an independent prognostic indicator.",

keywords = "Alpha B crystallin, BCL2, Breast cancer, Overall survival",

author = "Kim, {Mee Seon} and Lee, {Hyoun Wook} and Jun, {Si Youl} and Lee, {Eun Hee}",

year = "2015",

language = "English",

volume = "8",

pages = "8842--8856",

journal = "International Journal of Clinical and Experimental Pathology",

issn = "1936-2625",

number = "8",

}

Kim, MS, Lee, HW, Jun, SY & Lee, EH 2015, 'Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma', International Journal of Clinical and Experimental Pathology, vol. 8, no. 8, pp. 8842-8856.

Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma. / Kim, Mee Seon; Lee, Hyoun Wook; Jun, Si Youl et al.
In: International Journal of Clinical and Experimental Pathology, Vol. 8, No. 8, 2015, p. 8842-8856.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma

AU - Kim, Mee Seon

AU - Lee, Hyoun Wook

AU - Jun, Si Youl

AU - Lee, Eun Hee

PY - 2015

Y1 - 2015

N2 - Alpha B crystallin was characterized as a negative prognostic factor in breast cancer. BCL2 has an antiapoptotic role and sustains cell survival in vitro, ironically BCL2 expression has been associated with a good prognosis of breast cancer patients. To investigate the significance of alpha B crystallin and BCL2 expression in breast cancer and the relationship between these proteins, we performed immunohistochemical staining for both proteins in human breast cancer tissues. In the present study, overexpression of alpha B crystallin was observed more frequently in triple negative cancer (9/20, 45%) than in luminal type cancer (8/53, 15.1%, P=0.02161). BCL2 tended to be more highly expressed in luminal type cancer than in HER2 and triple negative cancer types (luminal: 36/53, 68%, HER2: 2/9, 22%, triple negative: 7/20 35%, P=0.008652). In multivariate analysis using ANCOVA, alpha B crystallin was related to short overall survival (P=0.017173). These findings suggest that alpha B crystallin is an independent prognostic factor of infiltrating ductal carcinoma. BCL2 was not associated with survival in multivariate analysis using ANCOVA. Thus, in our study BCL2 was not an independent prognostic indicator.

AB - Alpha B crystallin was characterized as a negative prognostic factor in breast cancer. BCL2 has an antiapoptotic role and sustains cell survival in vitro, ironically BCL2 expression has been associated with a good prognosis of breast cancer patients. To investigate the significance of alpha B crystallin and BCL2 expression in breast cancer and the relationship between these proteins, we performed immunohistochemical staining for both proteins in human breast cancer tissues. In the present study, overexpression of alpha B crystallin was observed more frequently in triple negative cancer (9/20, 45%) than in luminal type cancer (8/53, 15.1%, P=0.02161). BCL2 tended to be more highly expressed in luminal type cancer than in HER2 and triple negative cancer types (luminal: 36/53, 68%, HER2: 2/9, 22%, triple negative: 7/20 35%, P=0.008652). In multivariate analysis using ANCOVA, alpha B crystallin was related to short overall survival (P=0.017173). These findings suggest that alpha B crystallin is an independent prognostic factor of infiltrating ductal carcinoma. BCL2 was not associated with survival in multivariate analysis using ANCOVA. Thus, in our study BCL2 was not an independent prognostic indicator.

KW - Alpha B crystallin

KW - BCL2

KW - Breast cancer

KW - Overall survival

UR - http://www.scopus.com/inward/record.url?scp=85012982123&partnerID=8YFLogxK

M3 - Article

C2 - 26464626

AN - SCOPUS:85012982123

SN - 1936-2625

VL - 8

SP - 8842

EP - 8856

JO - International Journal of Clinical and Experimental Pathology

JF - International Journal of Clinical and Experimental Pathology

IS - 8

ER -

Kim MS, Lee HW, Jun SY, Lee EH. Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinoma. International Journal of Clinical and Experimental Pathology. 2015;8(8):8842-8856.